Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
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چکیده
منابع مشابه
Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus)
Glucose homeostasis is an important biological process that involves a variety of regulatory mechanisms. This study aimed to determine whether ghrelin, a multifunctional gut-brain hormone, modulates intestinal glucose transport in goldfish (Carassius auratus). Three intestinal glucose transporters, the facilitative glucose transporter 2 (GLUT2), and the sodium/glucose co-transporters 1 (SGLT1) ...
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ABOUT 180 g of glucose are filtered daily in the glomeruli of the kidneys in a healthy normoglycemic subject, which is equivalent to approximately one third of the total energy consumed by the human body in a day. Most of the glucose entering the tubular system is reabsorbed along the nephron segments, primarily in the proximal tubule, such that urine is almost free of glucose. This is differen...
متن کاملGlucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.
The human Na(+)/D-glucose cotransporter 2 (hSGLT2) is believed to be responsible for the bulk of glucose reabsorption in the kidney proximal convoluted tubule. Since blocking reabsorption increases urinary glucose excretion, hSGLT2 has become a novel drug target for Type 2 diabetes treatment. Glucose transport by hSGLT2 was studied at 37°C in human embryonic kidney 293T cells using whole cell p...
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Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-diabetic agents that improve glycemic control by inhibiting SGLT2-mediated renal glucose reabsorption. Currently available agents increase urinary glucose excretion (UGE) to <50% of maximal values because they do not inhibit SGLT1, which reabsorbs >50% of filtered glucose when SGLT2 is completely inhibited. This led ...
متن کاملFamilial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.
Four members of two glucose transporter families, SGLT1, SGLT2, GLUT1, and GLUT2, are differentially expressed in the kidney, and three of them have been shown to be necessary for normal glucose resorption from the glomerular filtrate. Mutations in SGLT1 are associated with glucose-galactose malabsorption, SGLT2 with familial renal glucosuria (FRG), and GLUT2 with Fanconi-Bickel syndrome. Patie...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2018
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-018-4656-5